SR8278
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $880 | Check With Us |
| 250mg | $1500 | Check With Us |
| 500mg | $2250 | Check With Us |
: Cat #: V9544 CAS #: 1254944-66-5 Purity ≥ 98%
Description: SR8278 (SR-8278; SR 8278) is a novel, potent, synthetic and competitive Rev-Erbα antagonist with the potential for treating Duchenne muscular dystrophy (DMD).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 361.48 |
|---|---|
| Molecular Formula | C18H19NO3S2 |
| CAS No. | 1254944-66-5 |
| SMILES Code | O=C(C1N(C(C2=CC=C(SC)S2)=O)CC3=C(C=CC=C3)C1)OCC |
| Synonyms | SR8278; SR 8278; SR-8278 |
| Protocol | In Vitro | SR8278 has REV-ERBα transcriptional repression inhibitory activity with an EC50 of 0.47μM. |
|---|---|---|
| In Vivo | SR8278 (slow microinjection; 20 μg/mouse) restores the binding activities of REV-ERBα and NURR1 to the tyrosine hydroxylase promoter and the induction of enrichment of the R/N motif, recognized by REV-ERBα and NURR1. SR8278 (slow microinjection; 20 μg/mouse) exerts antidepressant and anxiolytic effects in a circadian time-dependent manner in 6-OHDA-lesioned mice and restores the circadian rhythm of mood-related behaviors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7664 mL | 13.8320 mL | 27.6640 mL | 55.3281 mL |
| 5mM | 0.5533 mL | 2.7664 mL | 5.5328 mL | 11.0656 mL |
| 10mM | 0.2766 mL | 1.3832 mL | 2.7664 mL | 5.5328 mL |
| 20mM | 0.1383 mL | 0.6916 mL | 1.3832 mL | 2.7664 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.