SR33805
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $500 | Check With Us |
| 100mg | $850 | Check With Us |
| 200mg | $1275 | Check With Us |
: Cat #: V2210 CAS #: 121345-64-0 Purity ≥ 99%
Description: SR33805 is a novel and potent antagonist of Ca2+ channel with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively, and it blocks L-type but not T-type Ca2+ channels.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 564.74 |
|---|---|
| Molecular Formula | C32H40N2O5 |
| CAS No. | 121345-64-0 |
| SMILES Code | O=S(C1=CC=C(OCCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1)(C3=C(C(C)C)N(C)C4=C3C=CC=C4)=O |
| Synonyms | SR33805; SR-33805; SR 33805 |
| Protocol | In Vitro | SR33805 (10 µM; 10 min) restores the myocardial infarction (MI)-altered cell shortening without affecting the Ca2+ transient amplitude |
|---|---|---|
| In Vivo | SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats | |
| Animal model | Male Wistar rats (5 weeks) are subjected to coronary artery ligature | |
| Dosages | 0.2, 2, 20 mg/kg | |
| Administration | A single i.p. injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7707 mL | 8.8536 mL | 17.7073 mL | 35.4145 mL |
| 5mM | 0.3541 mL | 1.7707 mL | 3.5415 mL | 7.0829 mL |
| 10mM | 0.1771 mL | 0.8854 mL | 1.7707 mL | 3.5415 mL |
| 20mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 1.7707 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.