SR18662
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1800 | Check With Us |
| 500mg | $3000 | Check With Us |
| 1g | $4500 | Check With Us |
: Cat #: V2972 CAS #: 2505001-62-5 Purity ≥ 99%
Description: SR-18662 is an optimized anticancel agent based on ML264.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 420.31 |
|---|---|
| Molecular Formula | C16H19Cl2N3O4S |
| CAS No. | 2505001-62-5 |
| SMILES Code | O=C(NCC(N1CCN(S(=O)(C)=O)CC1)=O)/C=C/C2=CC=C(Cl)C(Cl)=C2 |
| Synonyms | SR18662; SR-18662; SR 18662; |
| Protocol | In Vitro | SR18662 (1 μM; 72 hours) reduces the expression of cyclins (cyclins E, A2, and B1) and components of MAPK (p-Erk) and WNT signaling pathways (p-GSK3 β) in cells. SR18662 (10 μM; 24-72 hours) shows a significant increase in the number of apoptotic cells at both early and late states in DLD-1 and HCT116 cells. SR18662 (0-10 μM; 24-72 hours) significantly reduces growth and proliferation of CRC cells as compared to treatment with vehicle control, ML264 (HY-19994). It shows improved efficacy in reducing viability of multiple CRC cell lines. |
|---|---|---|
| In Vivo | SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly reduces the growth of tumors in a mouse xenograft model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3792 mL | 11.8960 mL | 23.7920 mL | 47.5839 mL |
| 5mM | 0.4758 mL | 2.3792 mL | 4.7584 mL | 9.5168 mL |
| 10mM | 0.2379 mL | 1.1896 mL | 2.3792 mL | 4.7584 mL |
| 20mM | 0.1190 mL | 0.5948 mL | 1.1896 mL | 2.3792 mL |
The molarity calculator equation
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.