SR144528
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $635 | Check With Us |
| 100mg | $1050 | Check With Us |
| 200mg | $1575 | Check With Us |
: Cat #: V15224 CAS #: 192703-06-3 Purity ≥ 99%
Description: SR144528 (SR-144528; SR 144528) is a novel and potent cannabinoid (CB2) receptor or antagonist or inverse agonist with Ki of 0.6 nM and 400 nM against CB2 and CB1 receptors, respectively.
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- Related Biological Data
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| Molecular Weight (MW) | 476.05 |
|---|---|
| Molecular Formula | C29H34ClN3O |
| CAS No. | 192703-06-3 |
| Protocol | In Vitro | SR144528 is a potent and selective CB2 receptor antagonist with a Ki of 0.6 nM. SR144528 alone is able to stimulate in a concentration-dependent manner (EC50=26±6 nM, two experiments) the forskolin-sensitive adenylyl cyclase activity in CHO-CB2 cells with a maximum effect at 1 μM (4-fold stimulation) whereas at this concentration it has no significant effect on CHO-CB1 cells (15% inhibition) |
|---|---|---|
| In Vivo | SR144528 is a potent and selective CB2 receptor antagonist with a Ki of 0.6 nM. SR144528 alone is able to stimulate in a concentration-dependent manner (EC50=26±6 nM, two experiments) the forskolin-sensitive adenylyl cyclase activity in CHO-CB2 cells with a maximum effect at 1 μM (4-fold stimulation) whereas at this concentration it has no significant effect on CHO-CB1 cells (15% inhibition) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1006 mL | 10.5031 mL | 21.0062 mL | 42.0124 mL |
| 5mM | 0.4201 mL | 2.1006 mL | 4.2012 mL | 8.4025 mL |
| 10mM | 0.2101 mL | 1.0503 mL | 2.1006 mL | 4.2012 mL |
| 20mM | 0.1050 mL | 0.5252 mL | 1.0503 mL | 2.1006 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.