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| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | To Be Confirmed |
| 5mg | $700 | To Be Confirmed |
: Cat #: V43321 CAS #: 1816272-18-0 Purity ≥ 99%
Description: (S,R)-GSK321 is a potent and specific inhibitor of mutant IDH1. The IC50s for inhibiting R132G, R132C, R132H and WT IDH1 are 2.9, 3.8, 4.6 and 46 nM respectively. The selectivity is 100 times higher than that of IDH2. . (S,R)-GSK321 induces a decrease in intracellular 2-HG, fails to block myeloid differentiation, and induces granulocyte differentiation at the level of leukemic blasts and more immature stem cells. (S,R)-GSK321 may be utilized in study/research of acute myeloid leukemia (AML) and other cancers.
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| Molecular Weight (MW) | 501.55202960968 |
|---|---|
| Molecular Formula | C28H28FN5O3 |
| CAS No. | 1816272-18-0 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9938 mL | 9.9691 mL | 19.9381 mL | 39.8762 mL |
| 5mM | 0.3988 mL | 1.9938 mL | 3.9876 mL | 7.9752 mL |
| 10mM | 0.1994 mL | 0.9969 mL | 1.9938 mL | 3.9876 mL |
| 20mM | 0.0997 mL | 0.4985 mL | 0.9969 mL | 1.9938 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.