SR 59230A HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | Check With Us |
| 250mg | $1250 | Check With Us |
| 500mg | $1875 | Check With Us |
: Cat #: V15215 CAS #: 1135278-41-9 Purity ≥ 98%
Description: SR 59230A HCl is a potent, brain penetrant and selective β3 adrenoceptor antagonist with IC50 values of 40, 408 and 648 nM for β3, β1 and β2 receptors respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 361.91 |
|---|---|
| Molecular Formula | C21H28ClNO2 |
| CAS No. | 1135278-41-9 |
| Protocol | In Vivo | MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA |
|---|---|---|
| Animal model | Male C-57BL6J wild-type mice (22-35 g) | |
| Dosages | 0.5 or 5 mg/kg | |
| Administration | Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7631 mL | 13.8156 mL | 27.6312 mL | 55.2624 mL |
| 5mM | 0.5526 mL | 2.7631 mL | 5.5262 mL | 11.0525 mL |
| 10mM | 0.2763 mL | 1.3816 mL | 2.7631 mL | 5.5262 mL |
| 20mM | 0.1382 mL | 0.6908 mL | 1.3816 mL | 2.7631 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.