SPP-86
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | Check With Us |
| 200mg | $1575 | Check With Us |
| 500mg | $2660 | Check With Us |
: Cat #: V15181 CAS #: 1357349-91-7 Purity ≥ 99%
Description: SPP-86 (SPP86) is a novel, cell-permeable and potent RET tyrosine kinase inhibitor (IC50 of 8 nM) with anticancer activities.
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| Molecular Weight (MW) | 277.32 |
|---|---|
| Molecular Formula | C16H15N5 |
| CAS No. | 1357349-91-7 |
| SMILES Code | C1=CC(OC)=CC=C1S(=O)(=O)NCC1=CC=C(C(=O)NCCC2=CC=C(Cl)C=N2)C=C |
| Synonyms | YU238259; YU 238259; YU-238259; |
| Protocol | In Vitro | SPP86 (0-10 μM) inhibits RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells. SPP86 (0-10 μM) inhibits MAPK signaling and proliferation in RET/PTC1 expressing TPC1 but not 8505C or C643 cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6059 mL | 18.0297 mL | 36.0594 mL | 72.1189 mL |
| 5mM | 0.7212 mL | 3.6059 mL | 7.2119 mL | 14.4238 mL |
| 10mM | 0.3606 mL | 1.8030 mL | 3.6059 mL | 7.2119 mL |
| 20mM | 0.1803 mL | 0.9015 mL | 1.8030 mL | 3.6059 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.