SP-96

This product is for research use only, not for human use. We do not sell to patients.

SP-96
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$90To Be Confirmed
5mg$170To Be Confirmed
10mg$270To Be Confirmed
50mg$840To Be Confirmed
100mg$1340To Be Confirmed
email: [email protected]        [email protected]

Cat #: V35264 CAS #: 2682114-54-9 Purity ≥ 99%

Description: SP-96 is a specific and ATP-competitive Aurora B inhibitor (antagonist) with IC50 of 0.316 nM and >2000-fold selectivity for FLT3 and KIT. SP-96 displays selective growth inhibition in NCI60 screening and is selective for breast cancer cells such as MDA-MD-468 (GI50=107 nM). SP-96 may be utilized in research related to triple-negative breast cancer (TNBC).

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Molecular Weight (MW)453.47
Molecular FormulaC25H20FN7O
CAS No.2682114-54-9
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2052 mL11.0261 mL22.0522 mL44.1044 mL
5mM0.4410 mL2.2052 mL4.4104 mL8.8209 mL
10mM0.2205 mL1.1026 mL2.2052 mL4.4104 mL
20mM0.1103 mL0.5513 mL1.1026 mL2.2052 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.