Sovesudil (PHP-201; AMA0076)

This product is for research use only, not for human use. We do not sell to patients.

Sovesudil (PHP-201; AMA0076)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$170In Stock
5mg$420In Stock
10mg$720In Stock
email: [email protected]        [email protected]

Cat #: V35267 CAS #: 1333400-14-8 Purity ≥ 99%

Description: Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor (antagonist) with IC50s of 3.7 and 2.3 nM for ROCK I and ROCK II, respectively. Sovesudil lowers intraocular pressure without causing congestion.

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Molecular Weight (MW)407.44
Molecular FormulaC23H22FN3O3
CAS No.1333400-14-8
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4543 mL12.2717 mL24.5435 mL49.0870 mL
5mM0.4909 mL2.4543 mL4.9087 mL9.8174 mL
10mM0.2454 mL1.2272 mL2.4543 mL4.9087 mL
20mM0.1227 mL0.6136 mL1.2272 mL2.4543 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.