SNDX-5613 | CAS 2169919-21-3

SNDX-5613

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1300	Check With Us
200mg	$1950	Check With Us
500mg	$3290	Check With Us

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Cat #: V38964 CAS #: 2169919-21-3 Purity ≥ 99%

Description: SNDX-5613 (SNDX5613) is a novel, highly potent and selective inhibitor of Menin-MLL interaction with the potential to be used for MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

References: A drug, SNDX-5613, to treat acute leukemia with a KMT2A translocation or an NPM1 mutation that has come back (relapsed) or has not gotten better with treatment (refractory).

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Molecular Weight (MW)	630.82
Molecular Formula	C32H47FN6O4S
CAS No.	2169919-21-3
SMILES Code	O=C(C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(C3)CCN(CC4)C[C@H]5CC[C@@H](CC5)NS(=O)(CC)=O)N(C(C)C)CC
Synonyms	SNDX5613; SNDX 5613; SNDX-5613;

Protocol	In Vivo	Revumenib (SNDX-5613) shows in vivo plasma IC50 of 53 nM. Revumenib treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5852 mL	7.9262 mL	15.8524 mL	31.7048 mL
5mM	0.3170 mL	1.5852 mL	3.1705 mL	6.3410 mL
10mM	0.1585 mL	0.7926 mL	1.5852 mL	3.1705 mL
20mM	0.0793 mL	0.3963 mL	0.7926 mL	1.5852 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.