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| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | 3-6 Days |
| 10mg | $140 | 3-6 Days |
| 25mg | $220 | 3-6 Days |
| 50mg | $330 | 3-6 Days |
| 100mg | $470 | 3-6 Days |
| 250mg | $680 | 3-6 Days |
| 500mg | $960 | 3-6 Days |
: Cat #: V4432 CAS #: 1007647-73-5 Purity ≥ 99%
Description: Smurf1-IN-A01 is a novel, potent, high affinity and selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) with Kd value of 3.7 nM. It disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. Smurf1-IN-A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts. The ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) negatively regulates bone morphogenetic protein (BMP) pathway by ubiquitinating certain signal components for degradation. Thus, it can be an eligible pharmacological target for increasing BMP signal responsiveness.
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| Molecular Weight (MW) | 512.932413101196 |
|---|---|
| Molecular Formula | C22H20CLF3N4O3S |
| CAS No. | 1007647-73-5 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Synonyms | Smurf1 inhibitor A01; Smurf1-IN-A01; Smurf1-inhibitor-A01; Smurf1INA01; Smurf1 IN A01; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9496 mL | 9.7479 mL | 19.4957 mL | 38.9915 mL |
| 5mM | 0.3899 mL | 1.9496 mL | 3.8991 mL | 7.7983 mL |
| 10mM | 0.1950 mL | 0.9748 mL | 1.9496 mL | 3.8991 mL |
| 20mM | 0.0975 mL | 0.4874 mL | 0.9748 mL | 1.9496 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.