SMCC-DM1 | CAS 1228105-51-8

SMCC-DM1

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1880	Check With Us
500mg	$2600	Check With Us
1g	$3900	Check With Us

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Cat #: V4651 CAS #: 1228105-51-8 Purity ≥ 98%

Description: SMCC-DM1 (DM1-SMCC) is DM1 (mertansine) with a reactive linker SMCC to synthesize antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent. DM1 is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1 binds at the tips of microtubules and suppresses the dynamicity of microtubules.

References: [1]. Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28(8):1363-1370.

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Physicochemical and Storage Information
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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1072.61
Molecular Formula	C51H66ClN5O16S
CAS No.	1228105-51-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	C[C@@H]1[C@@H]2C[C@](NC(O2)=O)(O)[C@H](OC)/C=C\C=C(C)\CC3=CC(N(C)C(C[C@@H](OC([C@@H](N(C(CCSC(C(N4CC5CCC(C(ON6C(CCC6=O)=O)=O)CC5)=O)CC4=O)=O)C)C)=O)[C@@]7(C)C1O7)=O)=C(Cl)C(OC)=C3
Synonyms	DM1-SMCC; DM1SMCC; SMCC-DM1; DM1 SMCC;

Protocol	In Vitro	SMCC-DM1 inhibits HCC1954 and MDA-MB-468 cells proliferation with IC50s of 17.2 and 49.9 nM, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.9323 mL	4.6615 mL	9.3231 mL	18.6461 mL
5mM	0.1865 mL	0.9323 mL	1.8646 mL	3.7292 mL
10mM	0.0932 mL	0.4662 mL	0.9323 mL	1.8646 mL
20mM	0.0466 mL	0.2331 mL	0.4662 mL	0.9323 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.