SM16
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $900 | To Be Confirmed |
| 250mg | $1500 | To Be Confirmed |
| 500mg | $2250 | To Be Confirmed |
: Cat #: V14105 CAS #: 614749-78-9 Purity ≥ 98%
Description: SM16 is a novel and potent Type I TGF-β signaling inhibitor, also a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
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| Molecular Weight (MW) | 430.50 |
|---|---|
| Molecular Formula | C25H26N4Or3 |
| CAS No. | 614749-78-9 |
| Protocol | In Vitro | SM 16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC) at concentrations of 100 to 620 nM50=64 nM) and TGFβ- or activin-induced phosphorylation of Smad2. SM 16 was tested against >60 related and unrelated kinases, only against Raf (IC50=1 μM) 和 p38/SAPKa (IC50= 0.8 μM)。 SM 16 has no inhibitory activity against ALK1 and ALK6, members of the ALK family |
|---|---|---|
| In Vivo | SM 16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC) at concentrations of 100 to 620 nM50=64 nM) and TGFβ- or activin-induced phosphorylation of Smad2. SM 16 was tested against >60 related and unrelated kinases, only against Raf (IC50=1 μM) 和 p38/SAPKa (IC50= 0.8 μM)。 SM 16 has no inhibitory activity against ALK1 and ALK6, members of the ALK family |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3229 mL | 11.6144 mL | 23.2288 mL | 46.4576 mL |
| 5mM | 0.4646 mL | 2.3229 mL | 4.6458 mL | 9.2915 mL |
| 10mM | 0.2323 mL | 1.1614 mL | 2.3229 mL | 4.6458 mL |
| 20mM | 0.1161 mL | 0.5807 mL | 1.1614 mL | 2.3229 mL |
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Step One: Enter information below
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Average weight of animals g
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Number of animals
Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.