SIRT2-IN-11

This product is for research use only, not for human use. We do not sell to patients.

SIRT2-IN-11
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$130To Be Confirmed
5mg$270To Be Confirmed
10mg$440To Be Confirmed
email: [email protected]        [email protected]

Cat #: V36347 CAS #: 1005095-06-6 Purity ≥ 99%

Description: SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor (antagonist) with IC50 of 18.5 μM. SIRT2-IN-11 causes apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA and NOXA, and promotes acetylation of p53. SIRT2-IN-11 may be utilized in p53-related cancer research.

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Molecular Weight (MW)318.412185192108
Molecular FormulaC21H22N2O
CAS No.1005095-06-6
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: This product requires protection from light (avoid light exposure) during transportation and storage.

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1406 mL15.7029 mL31.4058 mL62.8117 mL
5mM0.6281 mL3.1406 mL6.2812 mL12.5623 mL
10mM0.3141 mL1.5703 mL3.1406 mL6.2812 mL
20mM0.1570 mL0.7851 mL1.5703 mL3.1406 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.