Simurosertib
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1040 | Check With Us |
| 250mg | $1800 | Check With Us |
| 500mg | $2700 | Check With Us |
: Cat #: V4595 CAS #: 1330782-76-7 Purity ≥ 98%
Description: Simurosertib (formerly known as TAK-931) is a novel, selective and orally bioavailable cycle 7 (CDC7, cell division cycle 7-related protein) kinase inhibitor with anticancer activity.
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| Molecular Weight (MW) | 341.43 |
|---|---|
| Molecular Formula | C17H19N5OS |
| CAS No. | 1330782-76-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | Simurosertib (TAK-931) potently inhibits CDC7 kinase activity (IC).50 <0.3 nM), with time-dependent ATP competitive dynamics for its ATP-binding pocket. Selective studies using 308 kinases have shown that Simurosertib (TAK-931) is more than 7-fold selective for CDC120 kinase inhibition compared to other kinase inhibition. Treatment with Simurosertib (TAK-931) inhibits cellular MCM40 phosphorylation at Ser2 (pMCM2) in a dose-dependent manner, resulting in delayed S-phase progression, DNA damage checkpoint activation, and caspase-3/7 activation |
|---|---|---|
| In Vivo | In a mouse model of COLO205 xenograft, oral administration of Simurosertib (TAK-931) inhibits the pMCM205 of xenograft COLO2 in a dose- and time-dependent manner. In addition, Simurosertib (TAK-931) exhibited significant antitumor activity in multiple xenograft models |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9289 mL | 14.6443 mL | 29.2886 mL | 58.5772 mL |
| 5mM | 0.5858 mL | 2.9289 mL | 5.8577 mL | 11.7154 mL |
| 10mM | 0.2929 mL | 1.4644 mL | 2.9289 mL | 5.8577 mL |
| 20mM | 0.1464 mL | 0.7322 mL | 1.4644 mL | 2.9289 mL |
The molarity calculator equation
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.