Sildenafil
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $350 | Check With Us |
| 10g | $500 | Check With Us |
| 20g | $750 | Check With Us |
: Cat #: V4198 CAS #: 139755-83-2 Purity ≥ 98%
Description: Sildenafil (formerly UK92480; UK-92480; Trade name: Revatio; VIAGRA), the free base form of Sildenafil, is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) with IC50 of 5.22 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 474.58 |
|---|---|
| Molecular Formula | C22H30N6O4S |
| CAS No. | 139755-83-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >30 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL |
| SMILES Code | CN1CCN(S(=O)(C2=CC=C(OCC)C(C(NC3=C4N(C)N=C3CCC)=NC4=O)=C2)=O)CC1 |
| Synonyms | UK-92480; UK 92480-10; UK 92480; UK92480 citrate; UK-92,480-10. Trade names: Revatio; VIAGRA |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1071 mL | 10.5356 mL | 21.0713 mL | 42.1425 mL |
| 5mM | 0.4214 mL | 2.1071 mL | 4.2143 mL | 8.4285 mL |
| 10mM | 0.2107 mL | 1.0536 mL | 2.1071 mL | 4.2143 mL |
| 20mM | 0.1054 mL | 0.5268 mL | 1.0536 mL | 2.1071 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.