Sibofimloc
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $500 | Check With Us |
| 500mg | $850 | Check With Us |
| 1g | $1275 | Check With Us |
: Cat #: V14751 CAS #: 1616113-45-1 Purity ≥ 98%
Description: Sibofimloc, formerly known as VRT-1353385 and Antibiotic-202, is an Escherichia coli fimbrial (FimH) adhesin inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 649.68 |
|---|---|
| Molecular Formula | C35H39NO11 |
| CAS No. | 1616113-45-1 |
| SMILES Code | CC(N1CCC2(CC1)C3=C(C4=C2C=C(C#C[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)C=C4)C=CC(C#C[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)=C3)=O |
| Synonyms | Antibiotic-202; Antibiotic 202; Antibiotic202; Sibofimloc; VRT-1353385; VRT 1353385; VRT1353385; |
| Protocol | In Vitro | FimH is a TLR4 receptor, expressed on E. coli and other Enterobacteriaceae in host with CD. The inhibition of FimH adhesion, and consequently intracellular replication of adherent-invasive E. coli in epithelial cells, may prevent establishment of a sub-mucosal infection leading to mucosal inflammation and epithelial barrier disruption. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5392 mL | 7.6961 mL | 15.3922 mL | 30.7844 mL |
| 5mM | 0.3078 mL | 1.5392 mL | 3.0784 mL | 6.1569 mL |
| 10mM | 0.1539 mL | 0.7696 mL | 1.5392 mL | 3.0784 mL |
| 20mM | 0.0770 mL | 0.3848 mL | 0.7696 mL | 1.5392 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.