Sibiromycin

This product is for research use only, not for human use. We do not sell to patients.

Sibiromycin
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$6750Check With Us
200mg$10120Check With Us
500mg$17050Check With Us

Cat #: V3767 CAS #: 12684-33-2 Purity ≥ 99%

Description: Sibiromycin is a natural and potent antitumor antibiotic .

References: Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293.

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Product Promise

Promise
Molecular Weight (MW)475.542
Molecular FormulaC24H33N3O7
CAS No.12684-33-2
SynonymsSibiromycin
ProtocolIn VitroPyrrolobenzodiazepines (PBDs) are sequence selective DNA alkylating agents with remarkable antineoplastic activity.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1029 mL10.5143 mL21.0286 mL42.0573 mL
5mM0.4206 mL2.1029 mL4.2057 mL8.4115 mL
10mM0.2103 mL1.0514 mL2.1029 mL4.2057 mL
20mM0.1051 mL0.5257 mL1.0514 mL2.1029 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.