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SGD-1882 HCl

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SGD-1882 HCl
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Cat #: V37585 CAS #: 222490-34-7 (free base) Purity ≥ 99%

Description: SGD1882 HCl (SGD-1882), the hydrochloride salt of SGD-1882, is a pyrrolobenzodiazepine (PBD) dimer and cytotoxic agent acting as a DNA minor-groove crosslinking agent and has been used as warheads in ADCs (Antibody-drug-conjugates).

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CAS No.222490-34-7 (free base)
ProtocolIn VitroSGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I.
These protocols are for reference only. InvivoChem does not independently validate these methods.
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.