SGC 0946
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $800 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V0399 CAS #: 1561178-17-3 Purity ≥ 98%
Description: SGC 0946 (SGC-0946; SGC0946) is a potent and selective inhibitor of DOT1L (DOT1 Like Histone Lysine Methyltransferase) with antineoplastic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 618.57 |
|---|---|
| Molecular Formula | C28H40BrN7O4 |
| CAS No. | 1561178-17-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (161.6 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 100 mg/mL (161.6 mM) | |
| SMILES Code | O=C(NC1=CC=C(CC(C)C)C=C1)NCCCN(C[C@H]2O[C@@H](N3C=C(Br)C4=C(N)N=CN=C43)[C@H](O)[C@@H]2O)C(C)C |
| Synonyms | SGC 0946; SGC0946; SGC-0946 |
| Protocol | In Vitro | SGC0946 (1 µM, 7 days) effectively inhibits MLL target genes, HOXA9 and Meis1. SGC0946 (1 µM; 3-7 days) shows time- and dose-dependent reductions in the H3K79me2 mark in the Molm13 MLL cell line that has the MLL/AF9 translocation. SGC0946 (1, 5 µM; 14 days) displays selective reduction of cell viability in an experimental leukaemia model derived from human cord blood cells (transformed with the MLL-AF9 fusion oncogene). SGC0946 (0-100 µM; 4 days) inhibits DOT1L with IC50 of 2.65 nM in A431 cells. |
|---|---|---|
| In Vivo | SGC0946 (10 mg/kg; i.p.; twice a week for 6 weeks) significantly suppresses tumor progression in a mouse orthotopic xenograft ovarian cancer model and also inhibits DOT1L enzymatic activity and levels of H3K79me2,CDK6, and cyclin D3 in the tumors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6166 mL | 8.0832 mL | 16.1663 mL | 32.3326 mL |
| 5mM | 0.3233 mL | 1.6166 mL | 3.2333 mL | 6.4665 mL |
| 10mM | 0.1617 mL | 0.8083 mL | 1.6166 mL | 3.2333 mL |
| 20mM | 0.0808 mL | 0.4042 mL | 0.8083 mL | 1.6166 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.