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| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | 3-6 Days |
| 10mg | $280 | 3-6 Days |
| 25mg | $460 | 3-6 Days |
| 50mg | $690 | 3-6 Days |
| 100mg | $1040 | 3-6 Days |
: Cat #: V14615 CAS #: 164301-51-3 Purity ≥ 99%
Description: Semapimod 4HCl, a novel and potent cytokine inhibitor, is the tetrahydrochloride salt of Semapimod mesylate (AXD 455; AIDS-121302; CNI-1493), which prevents the production of proinflammatory cytokines like TNF-α, IL-1β, and IL-6. In addition, it prevents macrophages from producing nitric oxide and inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod, an experimental new drug, has anti-inflammatory, anti-cytokine, immunomodulatory, antiviral, and antimalarial properties. Semapimod, a potential treatment for Crohn's disease and other inflammatory conditions, is a synthetic form of the mitogen-activated protein kinase inhibitor guanylhydrazone.
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| Molecular Weight (MW) | 744.9 |
|---|---|
| Molecular Formula | C34H52N18O2 |
| CAS No. | 164301-51-3 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Synonyms | Semapimod HCl; CNI-1493; CNI1493; CNI1493; AXD-455; AXD455; AXD 455; AIDS121302; AIDS-121302 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3425 mL | 6.7123 mL | 13.4246 mL | 26.8492 mL |
| 5mM | 0.2685 mL | 1.3425 mL | 2.6849 mL | 5.3698 mL |
| 10mM | 0.1342 mL | 0.6712 mL | 1.3425 mL | 2.6849 mL |
| 20mM | 0.0671 mL | 0.3356 mL | 0.6712 mL | 1.3425 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.