SDZ 220-581 hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | To Be Confirmed |
| 200mg | $1125 | To Be Confirmed |
| 500mg | $1770 | To Be Confirmed |
: Cat #: V32240 CAS #: 179411-93-9 Purity ≥ 99%
Description: SDZ 220-581 hydrochloride (SDZ220581; SDZ-220581) is a novel and competitive antagonist of NMDA glutamate receptor subtype (pKi= 7.7) with the potential to be used for Parkinson's disease.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 406.20 |
|---|---|
| Molecular Formula | C₁₆H₁₈Cl₂NO₅P |
| CAS No. | 179411-93-9 |
| Protocol | In Vivo | SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action |
|---|---|---|
| Animal model | Male OF-l mice (18-26 g) | |
| Dosages | 3.2 mg/kg, 10 mg/kg, 32 mg/kg | |
| Administration | Oral administration; for 24 hours |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4618 mL | 12.3092 mL | 24.6184 mL | 49.2368 mL |
| 5mM | 0.4924 mL | 2.4618 mL | 4.9237 mL | 9.8474 mL |
| 10mM | 0.2462 mL | 1.2309 mL | 2.4618 mL | 4.9237 mL |
| 20mM | 0.1231 mL | 0.6155 mL | 1.2309 mL | 2.4618 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.