SCR7 pyrazine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $685 | Check With Us |
| 250mg | $1238 | Check With Us |
| 500mg | $1857 | Check With Us |
: Cat #: V13089 CAS #: 14892-97-8 Purity ≥ 98%
Description: SCR7 pyrazine is a potent inhibitor of nonhomologous end-joining (NHEJ), enhancing CRISPR-Cas9-mediated homology-directed repair (HDR) in vitro.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 332.38 |
|---|---|
| Molecular Formula | C18H12N4OS |
| CAS No. | 14892-97-8 |
| Protocol | In Vitro | SCR7 pyrazine (20-100 μM; 24 hours; MCF7 cells) treatment interferes with NHEJ in cells, leading to accumulation of unrepaired double-strand breaks (DSBs) |
|---|---|---|
| In Vivo | CR7 pyrazine (10 mg/kg; intraperitoneal injection; six doses; BALB/c mice) treatment significantly reduces breast adenocarcinoma-induced tumor and increases lifespan | |
| Animal model | BALB/c mice injected with breast adenocarcinoma cells | |
| Dosages | 10 mg/kg | |
| Administration | ntraperitoneal injection; on alternate days (0, 2, 4, 6, 8, and 10) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0086 mL | 15.0430 mL | 30.0860 mL | 60.1721 mL |
| 5mM | 0.6017 mL | 3.0086 mL | 6.0172 mL | 12.0344 mL |
| 10mM | 0.3009 mL | 1.5043 mL | 3.0086 mL | 6.0172 mL |
| 20mM | 0.1504 mL | 0.7522 mL | 1.5043 mL | 3.0086 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.