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SCR-1481B1

This product is for research use only, not for human use. We do not sell to patients.

SCR-1481B1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$450Check With Us
500mg$750Check With Us
1g$1125Check With Us
email: [email protected]        [email protected]

Cat #: V2988 CAS #: 1174161-86-4 (tris) Purity ≥ 98%

Description: SCR-1481B1 (also known as c-Met inhibitor 2) is a novel potent and selective MET inhibitor.

References: Robert M. Borzilleri, et al. 4-pyridinone compounds and their use for cancer. WO/2009094417/A1.

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Molecular Weight (MW)742.07
Molecular FormulaC31H35ClF2N5O10P
CAS No.1174161-86-4 (tris)
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 30 mg/mLr
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeO=C(C1=CN(C=C(C1=O)C2=CC=C(C=C2)F)COP(O)(O)=O)NC3=CC=C(OC4=C(Cl)C(N)=NC=C4)C(F)=C3.NC(CCO)(CCO)CCO
SynonymsBMS-817378; BMS 817378; BMS817378; SCR-1481B1; SCR 1481B1; SCR1481B1
ProtocolIn VitroMore details please refer to Patent WO 2009094417 A1.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.3476 mL6.7379 mL13.4758 mL26.9516 mL
5mM0.2695 mL1.3476 mL2.6952 mL5.3903 mL
10mM0.1348 mL0.6738 mL1.3476 mL2.6952 mL
20mM0.0674 mL0.3369 mL0.6738 mL1.3476 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.