Schizandrin A
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $180 | Check With Us |
| 250mg | $300 | Check With Us |
| 500mg | $450 | Check With Us |
: Cat #: V8139 CAS #: 61281-38-7 Purity ≥ 99%
Description: Schizandrin A is a novel and potent bioactive compound.
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| Molecular Weight (MW) | 416.51 |
|---|---|
| Molecular Formula | C24H32O6 |
| CAS No. | 61281-38-7 |
| SMILES Code | C[C@H]1CC2=CC(OC)=C(OC)C(OC)=C2C3=C(OC)C(OC)=C(OC)C=C3C[C@H]1C |
| Synonyms | Deoxyschisandrin; Deoxyschizandrin; Schizandrin A |
| Protocol | In Vitro | Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The Ki value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The Kinact and Ki are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A. |
|---|---|---|
| In Vivo | Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4009 mL | 12.0045 mL | 24.0090 mL | 48.0181 mL |
| 5mM | 0.4802 mL | 2.4009 mL | 4.8018 mL | 9.6036 mL |
| 10mM | 0.2401 mL | 1.2005 mL | 2.4009 mL | 4.8018 mL |
| 20mM | 0.1200 mL | 0.6002 mL | 1.2005 mL | 2.4009 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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