SCH 563705
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3900 | To Be Confirmed |
| 250mg | $6600 | To Be Confirmed |
| 500mg | $9900 | To Be Confirmed |
: Cat #: V3795 CAS #: 473728-58-4 Purity ≥ 98%
Description: SCH-563705 (SCH563705) is a novel potent and orally bioactive antagonist of CXCR2 and CXCR1 with anti-Inflammatory and immunomodulatory activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 425.49 |
|---|---|
| Molecular Formula | C23H27N3O5 |
| CAS No. | 473728-58-4 |
| Storage | -20℃ for 3 years in powder formrrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 30 mg/mLrrr |
| Water: <1 mg/mLrrr | |
| Ethanol: <1 mg/mL | |
| Synonyms | SCH563705; SCH 563705; SCH-563705 |
| Protocol | In Vitro | SCH 563705 potently inhibits mouse CXCR2 (IC50 = 5.2 nM) |
|---|---|---|
| In Vivo | SCH 563705 (50 mg/kg p.o) reduces blood Ly6G+ Ly6C+ neutrophil frequency and unchanged levels of Ly6GLy6Chi monocytes. SCH563705 (3-30 mg/kg p.o) treatment causes a dosedependent elevation in plasma levels of CXCL1 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3502 mL | 11.7512 mL | 23.5023 mL | 47.0046 mL |
| 5mM | 0.4700 mL | 2.3502 mL | 4.7005 mL | 9.4009 mL |
| 10mM | 0.2350 mL | 1.1751 mL | 2.3502 mL | 4.7005 mL |
| 20mM | 0.1175 mL | 0.5876 mL | 1.1751 mL | 2.3502 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.