SCD1 inhibitor-4
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V2477 CAS #: 1295541-87-5 Purity ≥ 99%
Description: SCD1 inhibitor-4 is a novel, potent, and orally bioactive stearoylCoA desaturase-1 (SCD1) inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 363.34 |
|---|---|
| Molecular Formula | C17H16F3N5O |
| CAS No. | 1295541-87-5 |
| SMILES Code | O=C(C1=C(C)N(CC2=CC=CC(C(F)(F)F)=C2)C=N1)NC3=NN(C)C=C3 |
| Synonyms | SCD1 inhibitor-4; DUN41875; DUN-41875; DUN 41875 |
| Protocol | In Vivo | SCD1 inhibitor-4 (1~30 mg/kg) shows a dose-dependent decrease in desaturation index with a 55 % reduction at 1 mg/kg and 85% reduction at the 10 and 30 mg/kg doses. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7522 mL | 13.7612 mL | 27.5224 mL | 55.0449 mL |
| 5mM | 0.5504 mL | 2.7522 mL | 5.5045 mL | 11.0090 mL |
| 10mM | 0.2752 mL | 1.3761 mL | 2.7522 mL | 5.5045 mL |
| 20mM | 0.1376 mL | 0.6881 mL | 1.3761 mL | 2.7522 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.