SBFI-26 | CAS 1541207-06-0

SBFI-26

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Cat #: V37787 CAS #: 1541207-06-0 Purity ≥ 99%

Description: SBFI-26 (SBFI 26; SBFI26) is a novel, potent, specific and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7 with anti-nociceptive and anti-inflammatory activities. It inhibits FABP5/7 with Kis of 0.9 µM and 0.4 µM, respectively.

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Molecular Weight (MW)	422.47
Molecular Formula	C₂₈H₂₂O₄
CAS No.	1541207-06-0
SMILES Code	O=C([C@H]1[C@H](C2=CC=CC=C2)[C@H](C(O)=O)[C@H]1C3=CC=CC=C3)OC4=C5C=CC=CC5=CC=C4
Synonyms	SBFI 26; SBFI-26; SBFI26

Protocol	In Vitro	SBFI-26 binds to the canonical ligand-binding pocket of FABP5[1]. SBFI-26 significantly inhibits cellular AEA accumulation[2].
Protocol	In Vivo	SBFI-26 (20 mg/kg, i.p.) significantly reduces carrageenan-induced thermal hyperalgesia and paw edema[2]. SBFI-26 produces antinociceptive and anti-inflammatory effects in mice[2]. Animal Model: Mice[2] Dosage: 20 mg/kg Administration: Intraperitoneal injection Result: Significantly reduced carrageenan-induced thermal hyperalgesia and paw edema.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3670 mL	11.8352 mL	23.6703 mL	47.3406 mL
5mM	0.4734 mL	2.3670 mL	4.7341 mL	9.4681 mL
10mM	0.2367 mL	1.1835 mL	2.3670 mL	4.7341 mL
20mM	0.1184 mL	0.5918 mL	1.1835 mL	2.3670 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.