SB743921 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $1975 | Check With Us |
: Cat #: V1627 CAS #: 940929-33-9 Purity ≥ 98%
Description: SB743921 HCl (SB-743921; SB 743921), the hydrochloride salt of SB743921, is a novel and potent inhibitor of the mitotic motor protein, kinesin spindle protein (KSP), with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 553.52 |
|---|---|
| Molecular Formula | C31H33N2O3.HCl |
| CAS No. | 940929-33-9 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 111 mg/mL (200.5 mM)rr |
| Water: 22 mg/mL (39.7 mM)rr | |
| Ethanol: 111 mg/mL (200.5 mM) | |
| Solubility In Vivo | Saline pH5.0: 30 mg/mL |
| Synonyms | SB-743921; SB743921; SB 743921; SB-921; SB 921; SB921; GSK 921; GSK921; GSK-921; GSK921; GSK-743921; GSK 743921; GSK743921 |
| Protocol | In Vivo | SB-743921 has good oral bioavailability and pharmacokinetics and induces complete tumor regression in nude mice bearing lung cancer patient xenografts |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8066 mL | 9.0331 mL | 18.0662 mL | 36.1324 mL |
| 5mM | 0.3613 mL | 1.8066 mL | 3.6132 mL | 7.2265 mL |
| 10mM | 0.1807 mL | 0.9033 mL | 1.8066 mL | 3.6132 mL |
| 20mM | 0.0903 mL | 0.4517 mL | 0.9033 mL | 1.8066 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.