SB431542

This product is for research use only, not for human use. We do not sell to patients.

SB431542
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$750Check With Us
500mg$1150Check With Us
1g$1725Check With Us

Cat #: V1358 CAS #: 301836-41-9 Purity ≥ 98%

Description: SB431542 (SB-431542; SB 431542) is a novel and selective inhibitor of ALK5/TGF-β type I Receptor with potential antitumor activity.

References: Yi-qin Xiao, et al. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1698-706.

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Molecular Weight (MW)384.39
Molecular FormulaC22H16N4O3
CAS No.301836-41-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 77 mg/mL (200.3 mM)r
Water: <1 mg/mLr
Ethanol: 3 mg/mL (7.8 mM)
Solubility In Vivo2% DMSO+30% PEG 300+ddH2O: 5mg/mL
SynonymsSB431542; SB-431542; SB 431542
ProtocolIn VivoSB-431542 (subconjunctiva; 0.5 and 2 mM; Days 1, 2, 3, and 7) Inhibits scarring after glaucoma filtration surgery in New Zealand rabbits
Animal modelRabbits (3 to 5 months, 1.8 - 2.5 kg)
Dosages0.5 and 2 mM
Administration Subconjunctival injection, on days 1, 2, 3, and 7
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6015 mL13.0076 mL26.0152 mL52.0305 mL
5mM0.5203 mL2.6015 mL5.2030 mL10.4061 mL
10mM0.2602 mL1.3008 mL2.6015 mL5.2030 mL
20mM0.1301 mL0.6504 mL1.3008 mL2.6015 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.