Sacubitril (AHU-377)

This product is for research use only, not for human use. We do not sell to patients.

Sacubitril (AHU-377)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$90In Stock
25mg$130In Stock
50mg$160In Stock
100mg$260In Stock
250mg$390In Stock
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V4539 CAS #: 149709-62-6 Purity ≥ 99%

Description: Sacubitril (formerly known as AHU-377; Entresto) is a novel and potent NEP (neutral endopeptidase 24.11) inhibitor used in combination with valsartan (as LCZ696) for heart failure. It inhibits NEP with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696 (sacubitril in combination with valsartan). Sacubitril is a prodrug that can be activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.

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Molecular Weight (MW)411.49076
Molecular FormulaC24H29NO5
CAS No.149709-62-6
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsLCZ696; AHU377; LCZ 696; AHU 377; LCZ696; AHU-377; Entresto
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4302 mL12.1509 mL24.3019 mL48.6038 mL
5mM0.4860 mL2.4302 mL4.8604 mL9.7208 mL
10mM0.2430 mL1.2151 mL2.4302 mL4.8604 mL
20mM0.1215 mL0.6075 mL1.2151 mL2.4302 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.