S64315 (MIK665)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1800 | Check With Us |
| 200mg | $2700 | Check With Us |
| 500mg | $4555 | Check With Us |
: Cat #: V5242 CAS #: 1799631-75-6 Purity ≥ 98%
Description: MIK665 (also known as MIK-665; S-64315) is a novel, investigational and specific Mcl-1 inhibitor with an IC50 of 1.81 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 875.41 |
|---|---|
| Molecular Formula | C47H44ClFN6O6S |
| CAS No. | 1799631-75-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)[C@@H](CC1=C(OCC2=NC(C3=C(OC)C=CC=C3)=NC=C2)C=CC=C1)OC4=C5C(SC(C6=CC=C(F)C=C6)=C5C7=C(C)C(Cl)=C(OCCN8CCN(C)CC8)C=C7)=NC=N4 |
| Synonyms | S 64315; S-64315; S6431; MIK665; MIK-665; MIK 665; |
| Protocol | In Vitro | MIK665 (S-64315) has similar synergistic effects as S63845, when combined with ABT-199. The combination S64315 (0.156-10 μM) and ABT-199 (625 nM) has similar efficacy in reducing the cell viability of representative melanoma lines (MB2141, MB3616, MB3961, MB4667, A375, and 1205Lu cells). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.1423 mL | 5.7116 mL | 11.4232 mL | 22.8464 mL |
| 5mM | 0.2285 mL | 1.1423 mL | 2.2846 mL | 4.5693 mL |
| 10mM | 0.1142 mL | 0.5712 mL | 1.1423 mL | 2.2846 mL |
| 20mM | 0.0571 mL | 0.2856 mL | 0.5712 mL | 1.1423 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.