S63845 TFA
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1900 | To Be Confirmed |
| 200mg | $2850 | To Be Confirmed |
| 500mg | $4800 | To Be Confirmed |
: Cat #: V2800 CAS #: 1799633-27-4 (free base) Purity ≥ 98%
Description: S63845 TFA, the Trifluoroacetic acid salt of S63845, is a potent, selective small molecule inhibitor of MCL1 (myeloid cell leukemia 1) with Ki value < 1.2 nM.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 943.28 |
|---|---|
| Molecular Formula | C39H37ClF4N6O6S · C2HF3O2 |
| CAS No. | 1799633-27-4 (free base) |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >41.45mg/mLrr |
| Water: >10mg/mLrr | |
| Methanol: >20mg/mL | |
| SMILES Code | O=C(O)[C@@H](CC1=C(OCC2=CC=NN2CC(F)(F)F)C=CC=C1)OC3=C4C(SC(C5=CC=C(F)O5)=[C@@]4 [C@@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=NC=N3. |
| Synonyms | S63845 Trifluoroacetic acid; S-63845 TFA; S 63845 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.0601 mL | 5.3007 mL | 10.6013 mL | 21.2026 mL |
| 5mM | 0.2120 mL | 1.0601 mL | 2.1203 mL | 4.2405 mL |
| 10mM | 0.1060 mL | 0.5301 mL | 1.0601 mL | 2.1203 mL |
| 20mM | 0.0530 mL | 0.2650 mL | 0.5301 mL | 1.0601 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.