(S)-Ceralasertib ((S)-AZD6738)

This product is for research use only, not for human use. We do not sell to patients.

(S)-Ceralasertib ((S)-AZD6738)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$140To Be Confirmed
5mg$320To Be Confirmed
10mg$500To Be Confirmed
email: [email protected]        [email protected]

Cat #: V33138 CAS #: 1352226-87-9 Purity ≥ 99%

Description: (S)-Ceralasertib, the S-enantiomer of Ceralasertib (also known as AZD6738), is a novel, potent and orally bioavailable morpholino-pyrimidine-based, and selective inhibitor of the ATR (ataxia telangiectasia and rad3 related) kinase with IC50 of 2.5 nM. ATR is a serine/threonine protein kinase that is upregulated in various cancer cells, it plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA replication-associated stress. AZD6738 has potential anticancer activity against non-small cell lung cancer (NSCLC). AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1, which prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. AZD6738 also sensitizes tumor cells to chemo-(e,g, cisplatin) and radiotherapy.

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Molecular Weight (MW)412.5086
Molecular FormulaC20H24N6O2S
CAS No.1352226-87-9
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Synonyms(S)-Ceralasertib; 1352226-87-9; (S)-AZD6738; imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfane; BDBM60432; AZD6738; AZD 6738; SCHEMBL9979159;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4242 mL12.1210 mL24.2419 mL48.4838 mL
5mM0.4848 mL2.4242 mL4.8484 mL9.6968 mL
10mM0.2424 mL1.2121 mL2.4242 mL4.8484 mL
20mM0.1212 mL0.6060 mL1.2121 mL2.4242 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.