(S)-(-)-Bay-K-8644
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2380 | Check With Us |
| 1g | $3570 | Check With Us |
: Cat #: V4179 CAS #: 98625-26-4 Purity ≥ 98%
Description: (S)-(-)-Bay-K-8644, the S-enantiomer of Bay-K-8644, is a novel and potent Ca2+ channel activator that activates Ba2+ currents (IBa) with an EC50 of 32 nM.
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| Molecular Weight (MW) | 356.30 |
|---|---|
| Molecular Formula | C16H15F3N2O4 |
| CAS No. | 98625-26-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8066 mL | 14.0331 mL | 28.0662 mL | 56.1325 mL |
| 5mM | 0.5613 mL | 2.8066 mL | 5.6132 mL | 11.2265 mL |
| 10mM | 0.2807 mL | 1.4033 mL | 2.8066 mL | 5.6132 mL |
| 20mM | 0.1403 mL | 0.7017 mL | 1.4033 mL | 2.8066 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.