(-)-(S)-B-973B

This product is for research use only, not for human use. We do not sell to patients.

(-)-(S)-B-973B
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$850Check With Us
100mg$1450Check With Us
200mg$2175Check With Us

Cat #: V31453 CAS #: 2244989-34-0 Purity ≥ 99%

Description: (-)-(S)-B-973B is a novel and potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity.

References: Garai S, et al. B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ACS Med Chem Lett. 2018 Oct 11;9(11):1144-1148.

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Molecular Weight (MW)452.50
Molecular FormulaC₂₄H₂₆F₂N₆O
CAS No.2244989-34-0
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2099 mL11.0497 mL22.0994 mL44.1989 mL
5mM0.4420 mL2.2099 mL4.4199 mL8.8398 mL
10mM0.2210 mL1.1050 mL2.2099 mL4.4199 mL
20mM0.1105 mL0.5525 mL1.1050 mL2.2099 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.