RV521 | CAS 1903763-82-5

RV521

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V3810 CAS #: 1903763-82-5 Purity ≥ 98%

Description: RV521 is an orally bioactive, highly potent small-molecule inhibitor of RSV (respiratory syncytial virus) fusion protein. It is with promising pharmaceutical properties and is currently in clinical development for the treatment of RSV disease in paedriatrics, the elderly and immune-compromised patients. RV521 targets (RSV) fusion which is a surface protein that mediates RSV binding to cellular receptors. RSV infection has been an unmet medical need and RV521 is being developed to treat RSV in patients suffering with severe disease, including neonates, the elderly, the immunocompromised and those with underlying cardiovascular or respiratory disease.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	446.45
Molecular Formula	C23H22F4N4O
CAS No.	1903763-82-5
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mM
	Water: < 1mg/mL
	Ethanol: < 1mg/mL
Synonyms	RV521; RV-521; RV 521

Protocol	In Vitro	In vitro activity: Kinase Assay: Cell Assay:

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2399 mL	11.1995 mL	22.3989 mL	44.7978 mL
5mM	0.4480 mL	2.2399 mL	4.4798 mL	8.9596 mL
10mM	0.2240 mL	1.1199 mL	2.2399 mL	4.4798 mL
20mM	0.1120 mL	0.5600 mL	1.1199 mL	2.2399 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.