RUCAPARIB CAMSYLATE
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $710 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V3936 CAS #: 1859053-21-6 Purity ≥ 98%
Description: Rucaparib CAMSYLATE (AG014699; AG14447; PF01367338; trade name: Rubraca), the CAMSYLATE salt of rucaparib, is a potent PARP inhibitor approved by FDA for the treatment of ovarian cancer.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 555.67 |
|---|---|
| Molecular Formula | C29H34FN3O5S |
| CAS No. | 1859053-21-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 100 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Synonyms | AG014699 camsylate; PF-01367338; AG 014699; PF 01367338 camsylate; AG-014699; PF01367338; AG-14447 camsylate; AG 14447; AG14447 camsylate; Trade name: Rubraca |
| Protocol | In Vitro | Rucaparib (AG014699) monocamsylate is a possible N-demethylation metabolite of AG14644 |
|---|---|---|
| In Vivo | Rucaparib (AG014699) monocamsylate and AG14584 significantly increase Temozolomide toxicity. Rucaparib (1 mg/kg) monocamsylate significantly increases Temozolomide-induced body weight loss. Rucaparib (0.1 mg/kg) monocamsylate results in a 50% increase in the temozolomide-induced tumor growth delay |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7996 mL | 8.9981 mL | 17.9963 mL | 35.9926 mL |
| 5mM | 0.3599 mL | 1.7996 mL | 3.5993 mL | 7.1985 mL |
| 10mM | 0.1800 mL | 0.8998 mL | 1.7996 mL | 3.5993 mL |
| 20mM | 0.0900 mL | 0.4499 mL | 0.8998 mL | 1.7996 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.