Rucaparib (AG-014699)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V3935 CAS #: 283173-50-2 Purity ≥ 98%
Description: Rucaparib (formerly known as AG-14447; AG-014699; PF-01367338; Rubraca) is an inhibitor of PARP [ (poly(ADP-Ribose) polymerase)] with anticancer effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 323.37 |
|---|---|
| Molecular Formula | C19H18FN3O |
| CAS No. | 283173-50-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| Synonyms | AG014699; PF-01367338; AG 14447; AG 014699; PF 01367338; AG-014699,PF01367338; AG-14447; AG14447; Trade name: Rubraca |
| Protocol | In Vitro | Rucaparib (AG014699) is a possible N-demethylation metabolite of AG14644 |
|---|---|---|
| In Vivo | Rucaparib (AG014699) and AG14584 significantly increase Temozolomide toxicity. Rucaparib (1 mg/kg) significantly increases Temozolomide-induced body weight loss. Rucaparib (0.1 mg/kg) results in a 50% increase in the temozolomide-induced tumor growth delay | |
| Animal model | Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells | |
| Dosages | 10 mg/kg for i.p. or 50, 150 mg/kg for p.o. | |
| Administration | IP or PO |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0924 mL | 15.4622 mL | 30.9243 mL | 61.8487 mL |
| 5mM | 0.6185 mL | 3.0924 mL | 6.1849 mL | 12.3697 mL |
| 10mM | 0.3092 mL | 1.5462 mL | 3.0924 mL | 6.1849 mL |
| 20mM | 0.1546 mL | 0.7731 mL | 1.5462 mL | 3.0924 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.