RU-301
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1700 | Check With Us |
| 500mg | $2500 | Check With Us |
| 1g | $3750 | Check With Us |
: Cat #: V14260 CAS #: 1110873-99-8 Purity ≥ 98%
Description: RU-301 is a novel pan-tam inhibitor, that exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with Kd and IC50 values of 12 μM and 10 μM, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 480.46 |
|---|---|
| Molecular Formula | C21H19F3N4O4S |
| CAS No. | 1110873-99-8 |
| SMILES Code | O=C(NCCNC1=CC=C(C(F)(F)F)C([N+]([O-])=O)=C1)C2=CC=CC=C2SCC3=CC(C)=NO3 |
| Synonyms | RU-301; RU 301; RU301; |
| Protocol | In Vitro | RU-301 (10 μM; 14 days) inhibits growth of H1299 clonogenic cells under Gas6. RU-301 (10 μM; 24 h) inhibits migration of H1299 and MDA-MB-231 cells. RU-301 (10 μM; 30 min) inhibits native TAMs activation in H1299 cells. |
|---|---|---|
| In Vivo | RU-301 (100, 300 mg/kg; i.p.; single daily for 4 days) inhibits tumor growth in lung cancer xenograft model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0813 mL | 10.4067 mL | 20.8134 mL | 41.6268 mL |
| 5mM | 0.4163 mL | 2.0813 mL | 4.1627 mL | 8.3254 mL |
| 10mM | 0.2081 mL | 1.0407 mL | 2.0813 mL | 4.1627 mL |
| 20mM | 0.1041 mL | 0.5203 mL | 1.0407 mL | 2.0813 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.