Rosuvastatin Sodium

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
25g	$450	Check With Us
50g	$750	Check With Us
100g	$1125	Check With Us

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Cat #: V40844 CAS #: 147098-18-8 Purity ≥ 99%

Description: Rosuvastatin sodium (formerly S4522; ZD-4522, trade name: Crestor), the sodium salt of Rosuvastatin, is an HMG-CoA reductase inhibitor approved for the treatment of high cholesterol and related conditions such as dyslipidemia, and to prevent cardiovascular disease.

References: Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

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Physicochemical and Storage Information
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Stock Solution Preparation
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Molecular Weight (MW)	503.52
Molecular Formula	C22H27FN3NaO6S
CAS No.	147098-18-8
Synonyms	Rosuvastatin Sodium; S4522; ZD-4522; trade name: Crestor

Protocol	In Vivo	Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9860 mL	9.9301 mL	19.8602 mL	39.7204 mL
5mM	0.3972 mL	1.9860 mL	3.9720 mL	7.9441 mL
10mM	0.1986 mL	0.9930 mL	1.9860 mL	3.9720 mL
20mM	0.0993 mL	0.4965 mL	0.9930 mL	1.9860 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.