RON-IN-1 (AMG-1)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1250 | Check With Us |
| 1g | $1850 | Check With Us |
| 5g | $4685 | Check With Us |
: Cat #: V7192 CAS #: 913376-84-8 Purity ≥ 98%
Description: RON-IN-1 (AMG-1) is a novel, potent and cell-permeable inhibitor of RON, also acts by inhibiting c-Met.
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- Related Biological Data
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| Molecular Weight (MW) | 556.58 |
|---|---|
| Molecular Formula | C31H29FN4O5 |
| CAS No. | 913376-84-8 |
| SMILES Code | COC1=CC2=NC=CC(C3=CC=C(NC(C4=C(C)N(CC(C)(O)C)N(C5=CC=CC=C5)C4=O)=O)C=C3F)=C2C=C1 |
| Synonyms | RON inhibitor-1; RON IN 1; Ron Inhibitor I; RON-IN-1; RONIN1; Met Kinase Inhbitor IV; RON inhibitor 1; |
| Protocol | In Vitro | SYN1143 (10-1000 nM; 1 h) inhibits RON-mediated signaling and functional activity in NIH3T3 RON and BxPC3 cells. SYN1143 (Compound I) (10-1000 nM; 1 h) inhibits c-Met-mediated signaling and functional activity in HT-29 and BxPC3 cells. |
|---|---|---|
| In Vivo | SYN1143 (10-100 mg/kg; p.o. for 22 d) inhibits the growth of c-Met-dependent and constitutively active RON-expressing tumors in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7967 mL | 8.9834 mL | 17.9669 mL | 35.9337 mL |
| 5mM | 0.3593 mL | 1.7967 mL | 3.5934 mL | 7.1867 mL |
| 10mM | 0.1797 mL | 0.8983 mL | 1.7967 mL | 3.5934 mL |
| 20mM | 0.0898 mL | 0.4492 mL | 0.8983 mL | 1.7967 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.