RO 28-1675 (Ro 0281675)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2025 | To Be Confirmed |
| 200mg | $3035 | To Be Confirmed |
| 500mg | $5120 | To Be Confirmed |
: Cat #: V13883 CAS #: 300353-13-3 Purity ≥ 98%
Description: Ro 28-1675 (Ro-0281675) is a novel, potent and allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.
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| Molecular Weight (MW) | 378.51 |
|---|---|
| Molecular Formula | C18H22N2O3S2 |
| CAS No. | 300353-13-3 |
| SMILES Code | O=C(NC1=NC=CS1)[C@@H](C2=CC=C(S(=O)(C)=O)C=C2)CC3CCCC3 |
| Synonyms | RO 281675; RO-281675; Ro 0281675; Ro-0281675; Ro0281675; RO28-1675; RO-28-1675; RO 28-1675; RO028-1675; RO-028-1675; RO 028-1675; RO281675; |
| Protocol | In Vitro | RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP). |
|---|---|---|
| In Vivo | RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and Cmax (1140 μg/mL) following oral administration (10 mg/kg). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6419 mL | 13.2097 mL | 26.4194 mL | 52.8388 mL |
| 5mM | 0.5284 mL | 2.6419 mL | 5.2839 mL | 10.5678 mL |
| 10mM | 0.2642 mL | 1.3210 mL | 2.6419 mL | 5.2839 mL |
| 20mM | 0.1321 mL | 0.6605 mL | 1.3210 mL | 2.6419 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.