Rimegepant (BMS927711)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1200	Check With Us
500mg	$1700	Check With Us
1g	$2550	Check With Us

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Cat #: V4067 CAS #: 1289023-67-1 Purity ≥ 98%

Description: Rimegepant (formerly known as BMS-927711; Nurtec ODT) is a highly potent, selective, orally bioavailable, cometitive calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.

References: Luo G, et al. Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) a

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	534.57
Molecular Formula	C28H28F2N6O3
CAS No.	1289023-67-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	FC1=CC=CC([C@H]2[C@H](N)C(C=CC=N3)=C3[C@H](OC(N4CCC(N5C6=C(N=CC=C6)NC5=O)CC4)=O) CC2)=C1F
Synonyms	BMS-927711; BMS 927711; BMS927711

Protocol	In Vitro	Rimegepant (BMS-927711) is a full, competitive CGRP receptor antagonist with IC50 of 0.14±0.01 nM
Protocol	In Vivo	Rimegepant (BMS-927711) has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical properties, and shows dose-dependent activity in a primate model of CGRP-induced facial blood flow

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8707 mL	9.3533 mL	18.7066 mL	37.4132 mL
5mM	0.3741 mL	1.8707 mL	3.7413 mL	7.4826 mL
10mM	0.1871 mL	0.9353 mL	1.8707 mL	3.7413 mL
20mM	0.0935 mL	0.4677 mL	0.9353 mL	1.8707 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.