Rilpivirine (R278474; TMC278)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $920 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V1819 CAS #: 500287-72-9 Purity ≥ 98%
Description: Rilpivirine (formerly known as R278474; TMC278; DB08864; Edurant; Rekambys; Cabenuva), an approved HIV drug, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that has been widely used for the treatment of HIV-1 infection.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 366.42 |
|---|---|
| Molecular Formula | C22H18N6 |
| CAS No. | 500287-72-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 73 mg/mL (199.2 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | R-278474, DB08864, TMC278; R 278474, D08864, TMC-278; R278474, D08864, TMC 278; Rilpivirine; Rekambys; Cabenuva; Edurant. |
| Protocol | In Vitro | R278474 inhibits 81% of clinical isolates (about 1200 recombinant clinical isolates) at a 50% inhibitory concentration (EC50) less than 1 nM, and inhibits 94% at EC50 less than 10 nM |
|---|---|---|
| In Vivo | R278474 (10-160 mg/kg; p.o. for 1 month) does not produce abnormal effects in rat, apart from liver weight increase and species-specific thyroid hypertrophy, both at the higher dose levels |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7291 mL | 13.6455 mL | 27.2911 mL | 54.5822 mL |
| 5mM | 0.5458 mL | 2.7291 mL | 5.4582 mL | 10.9164 mL |
| 10mM | 0.2729 mL | 1.3646 mL | 2.7291 mL | 5.4582 mL |
| 20mM | 0.1365 mL | 0.6823 mL | 1.3646 mL | 2.7291 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.