Rilpivirine HCl (TMC278; DB08864)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$485	Check With Us
500mg	$850	Check With Us
1g	$1275	Check With Us

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Cat #: V2143 CAS #: 700361-47-3 Purity ≥ 98%

Description: Rilpivirine HCl (TMC-278; R-278474 HCl; DB-08864; Edurant; Rekambys; Cabenuva), the hydrochloride salt of Rilpivirine, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that has been approved for the treatment of HIV-1 infections.

References: Shiori Haga, et al. TACE Antagonists Blocking ACE2 Shedding Caused by the Spike Protein of SARS-CoV Are Candidate Antiviral Compounds. Antiviral Res. 2010 Mar;85(3):551-5.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	402.88
Molecular Formula	C22H19ClN6
CAS No.	700361-47-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 73 mg/mL (199.2 mM)r
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	TMC-278; R-278474 HCl; DB-08864; DB08864, TMC278; D08864; TMC-278; R-278474; Edurant; Rekambys; Cabenuva; R-278474, R278474, D08864, TMC 278; Rilpivirine HCl; Edurant.

Protocol	In Vitro	R278474 is active against wild-type HIV-1 (EC50=0.4 nM) and all tested single and double mutants (ECs).50=0.1-2.0 nM)
Protocol	In Vivo	R278474 (10-160 mg/kg; p.o. for 1 month) does not produce abnormal effects in rat, apart from liver weight increase and species-specific thyroid hypertrophy, both at the higher dose levels

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4821 mL	12.4106 mL	24.8213 mL	49.6426 mL
5mM	0.4964 mL	2.4821 mL	4.9643 mL	9.9285 mL
10mM	0.2482 mL	1.2411 mL	2.4821 mL	4.9643 mL
20mM	0.1241 mL	0.6205 mL	1.2411 mL	2.4821 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.