Rigosertib sodium (ON-01910)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$650	Check With Us
500mg	$990	Check With Us
1g	$1480	Check With Us

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Cat #: V1575 CAS #: 1225497-78-8 Purity ≥ 98%

Description: Rigosertib sodium (formerly known as ON-01910; ON01910; Estybon), the sodium salt of Rigosertib, is a novel, potent and non-ATP-competitive inhibitor of PLK1 with potential anticancer activity.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	473.47
Molecular Formula	C21H24NNaO8S
CAS No.	1225497-78-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 95 mg/mL (200.6 mM)r
	Water: 95 mg/mL (200.6 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	ON-01910; Rigosertib sodium; ON01910; ON 01910; brand name: Estybon

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1121 mL	10.5603 mL	21.1207 mL	42.2413 mL
5mM	0.4224 mL	2.1121 mL	4.2241 mL	8.4483 mL
10mM	0.2112 mL	1.0560 mL	2.1121 mL	4.2241 mL
20mM	0.1056 mL	0.5280 mL	1.0560 mL	2.1121 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.