RG7388 (Idasanutlin)

This product is for research use only, not for human use. We do not sell to patients.

RG7388 (Idasanutlin)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$90In Stock
25mg$140In Stock
50mg$230In Stock
100mg$390In Stock
250mg$610In Stock
500mg$840In Stock
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V3264 CAS #: 1229705-06-9 Purity ≥ 99%

Description: RG7388 (also known as Idasanutlin; RG-7388; RO5503781) is a novel, potent and highly selective antagonist of the p53-MDM2 protein-protein interaction with potential antitumor activity. With an IC50 of 6 nM, it prevents the interaction of p53 and MDM2. Inhibiting the interaction between p53 and MDM2 in order to restore p53 activity has been viewed as a promising method for treating cancer. To create small-molecule inhibitors with desirable pharmacological profiles, the hydrophobic protein-protein interaction surface poses a significant challenge. MDM2 (mouse double minute 2; Mdm2 p53 binding protein homolog) is a tumor suppressor protein that interacts with p53. By binding to MDM2, RG7388 blocks this interaction and has an effect. When the MDM2-p53 interaction is broken, p53 is not enzymatically degraded and its transcriptional activity is reinstated, which leads to the p53-mediated induction of tumor cell apoptosis. MDM2 is a p53 pathway negative regulator that is frequently overexpressed in tumor cells. As an MDM2 antagonist, RG7388 may have anticancer properties.

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Molecular Weight (MW)616.48
Molecular FormulaC31H29Cl2F2N3O4
CAS No.1229705-06-9
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsIdasanutlin; RG-7388; RO-5503781; RG 7388; RO5503781; 1229705-06-9; RG7388; RG-7388; Idasanutlin (RG-7388); Idasanutlin (RG7388); RO5503781; 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid; RG7388; RO 5503781
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.6221 mL8.1106 mL16.2211 mL32.4423 mL
5mM0.3244 mL1.6221 mL3.2442 mL6.4885 mL
10mM0.1622 mL0.8111 mL1.6221 mL3.2442 mL
20mM0.0811 mL0.4055 mL0.8111 mL1.6221 mL
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.