RG 13022
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1360 | Check With Us |
| 1g | $2040 | Check With Us |
: Cat #: V9597 CAS #: 136831-48-6 Purity ≥ 99%
Description: RG 13022 is a novel and potent inhibitor of epidermal growth factor (EGF).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 266.29 |
|---|---|
| Molecular Formula | C16H14N2O2 |
| CAS No. | 136831-48-6 |
| SMILES Code | N#C/C(C1=CC=CN=C1)=C/C2=CC=C(OC)C(OC)=C2 |
| Synonyms | Tyrphostin RG 13022; RG 13022; RG13022; RG-13022. |
| Protocol | In Vitro | RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC50s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. |
|---|---|---|
| In Vivo | RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7553 mL | 18.7765 mL | 37.5530 mL | 75.1061 mL |
| 5mM | 0.7511 mL | 3.7553 mL | 7.5106 mL | 15.0212 mL |
| 10mM | 0.3755 mL | 1.8777 mL | 3.7553 mL | 7.5106 mL |
| 20mM | 0.1878 mL | 0.9388 mL | 1.8777 mL | 3.7553 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.