RETV804M inhibitor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | To Be Confirmed |
| 10mg | $150 | To Be Confirmed |
| 25mg | $250 | To Be Confirmed |
| 50mg | $450 | To Be Confirmed |
| 100mg | $750 | To Be Confirmed |
| 250mg | $1250 | To Be Confirmed |
| 500mg | $1950 | To Be Confirmed |
: Cat #: V2174 CAS #: 2414373-42-3 Purity ≥ 98%
Description: RETV804M inhibitor is a novel, potent and selective RET/KDR inhibitor with IC50 of 7 nM. Reference: ACS Med Chem Lett . 2020 Feb 28;11(4):497-505 (compound 5).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 344.378 |
|---|---|
| Molecular Formula | C19H16N6O |
| CAS No. | 2414373-42-3 |
| SMILES Code | O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=NC=C4)C=CN3N=C2)C=C1 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9038 mL | 14.5189 mL | 29.0379 mL | 58.0757 mL |
| 5mM | 0.5808 mL | 2.9038 mL | 5.8076 mL | 11.6151 mL |
| 10mM | 0.2904 mL | 1.4519 mL | 2.9038 mL | 5.8076 mL |
| 20mM | 0.1452 mL | 0.7259 mL | 1.4519 mL | 2.9038 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.